Senior Scientist 1, Biophysical Characterization
Location: San Rafael
Posted on: June 23, 2025
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Job Description:
Who We Are At BioMarin , we are driven by a singular mission: to
transform lives through bold science. As a global biotechnology
leader, we specialize in translating genetic discoveries into
groundbreaking therapies that redefine the future of human
health.Since 1997, we’ve leveraged our deep expertise in genetics
and molecular biology to develop innovative treatments for rare and
serious genetic conditions. Our approach is rooted in scientific
rigor, a passion for solving complex problems, and a commitment to
delivering meaningful advances for patients with unmet medical
needs.We bring together top-tier talent—scientists, innovators, and
problem-solvers—and foster a collaborative environment where bold
ideas thrive. This has enabled us to build a diverse pipeline of
commercial, clinical, and preclinical candidates with the potential
to be first-in-class or best-in-class therapies. About Worldwide
Research and Development (WWRD) WWRD spans the full spectrum of
drug development—from early discovery through post-market clinical
research. Our integrated teams work across disciplines to develop
transformative therapies that make a real difference in the lives
of patients with genetic diseases. Position: Senior Scientist,
Biophysical Characterization Location: San Rafael, CA Department:
Research & Early Development – Therapeutic Modality Team We are
seeking a Senior Scientist in Biophysical Characterization to help
shape the future of next-generation biologics, bioconjugates, and
non-viral nanoparticle delivery systems. This is a unique
opportunity for a scientifically rigorous, forward-thinking
biophysicist to drive innovation at the intersection of discovery
and translational science.As a key member of the Therapeutic
Modality Team, you will lead the development of advanced
biophysical workflows, design custom assays to elucidate mechanisms
of action, and serve as a strategic analytical expert. Your
insights will directly influence candidate selection,
manufacturability, and regulatory strategy—accelerating the journey
from bench to bedside. Key Responsibilities Strategic Leadership in
Biophysical Characterization Design and lead scalable,
phase-appropriate biophysical strategies for complex therapeutic
modalities aligned with program goals. Assay Development &
Innovation Develop and validate robust assays to assess
higher-order structure, aggregation, stability, and target
engagement. Cross-Functional Collaboration Partner with discovery,
process development, formulation, and regulatory teams to integrate
biophysical insights into decision-making. Technology Transfer &
External Partnerships Lead assay transfer to Analytical Sciences
and external partners (CROs/CDMOs), including preparation of
comprehensive tech transfer packages. Scientific Innovation &
External Engagement Stay at the forefront of emerging technologies.
Collaborate with academic and industry partners to evaluate novel
platforms and delivery strategies. Regulatory Support Generate
high-quality data packages for regulatory submissions (e.g., INDs)
and ensure compliance with internal and global standards.
Mentorship & Culture Building Mentor junior scientists and
contribute to a culture of scientific excellence, innovation, and
continuous learning. Qualifications Education: Ph.D. in Biophysics,
Biochemistry, or a related field M.S. or B.S. candidates with
exceptional experience will also be considered Experience: Ph.D.
with 6 years, M.S. with 10 years, or B.S. with 12 years of relevant
industry experience Expertise in characterizing protein-based
biologics, bioconjugates, and/or nanoparticle delivery systems
Proven track record supporting regulatory submissions with complex
molecule characterization Hands-on experience with techniques such
as DLS, FFF-MALS, SEC-MALS, CAD-HPLC, AUC, DSC, CD, FTIR, ITC, SPR
Familiarity with high-throughput screening, automation, and
AI-driven data analysis is a plus Core Competencies Strong
problem-solving and critical thinking skills Excellent scientific
writing and communication abilities Proven leadership in
cross-functional, matrixed environments Demonstrated initiative in
adopting and implementing innovative technologies Preferred
Qualifications Experience developing therapeutic release assays
across development stages Successful assay technology transfer to
CROs/CDMOs Familiarity with regulatory submissions and health
authority interactions Strong record of innovation (e.g., patents,
peer-reviewed publications) Additional Information This job
description is intended to convey essential responsibilities and
qualifications. It is not an exhaustive list of all duties or
expectations. Equal Opportunity Employer BioMarin is an Equal
Opportunity Employer. All qualified applicants will receive
consideration for employment without regard to race, color,
religion, sex, sexual orientation, gender identity, national
origin, protected veteran status, or disability.
Keywords: , North Highlands , Senior Scientist 1, Biophysical Characterization, Science, Research & Development , San Rafael, California
